You are likely remiss if you think you are an exception to be supplementing with vitamin D. A recent (and largest ever) meta-analysis evaluating vitamin D revealed several notable truths:
- Medicine took a very long time to realize that vitamin D is not simply a vitamin that prevents rickets.
- We know today that vitamin D is a powerful nuclear receptor-activating hormone of critical importance, especially to the immune system.
- All-disease (autoimmune diseases, metabolic syndrome, type 2 diabetes, cancer) mortality risk is reduced to 1.0 with serum vitamin D levels ≥100 nmol/L.
- In a correct analysis of the data used by the Institute of Medicine, it was found that 8895 IU/d was needed for 97.5% of individuals to achieve values ≥50 nmol/L (20ng/mL). Another study confirmed that 6201 IU/d was needed to achieve 75 nmol/L (30ng/mL) and 9122 IU/d was needed to reach 100 nmol/L (40ng/mL).
- The largest meta-analysis ever conducted of studies published between 1966 and 2013 showed that 25-hydroxyvitamin D levels <75 nmol/L may be too low for safety and associated with higher all-cause mortality.
Take away: Invest in some vitamin D asap.
Side note: Associations are being drawn between long-term vitamin D deficiency and Alzheimer's Disease. https://www.ncbi.nlm.nih.gov/pubmed/24413618
Read more on the vitamin D meta-analysis here - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541280/